Hepatocyte stat3
Web5 mei 2014 · Hepatocyte STAT3 and RelA were functionally deleted using the CRE- LoxP system. Briefly, mice with homozygous floxed alleles for Stat3 and RelA were crossed with mice expressing CRE-recombinase under transcriptional control of an albumin promoter. Web1 mrt. 2008 · The augmentative effect of c-Fos required the presence of STAT3 and 3'-hepatocyte NF-1 (HNF-1) RE, which were eliminated by dominant negative STAT3 and …
Hepatocyte stat3
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Web26 feb. 2024 · Zone 3 hepatocytes, near the central vein, labeled with Axin2-CreER have been reported to give rise to substantial numbers of hepatocytes under homeostatic conditions in the adult liver ( 3 ); however, this observation was most recently challenged by an alternative Axin2 reporter allele using a bacterial artificial chromosome CreER … Web19 feb. 2024 · Activating STAT3 upon binding to its receptor, IL-11 protects a variety of organs including the liver by suppressing inflammation. For example, IL-11 administration significantly attenuates acetaminophen-induced hepatic injury through downregulation of tumor necrosis factor-α (TNF-α) [ 12 ].
WebMD,PhD, FEBCTS, PHO, AO, Cardiothoracic and Transplant Surgeon, Public Health Officer 6d Web12 apr. 2024 · PCR products of STAT3 were sequenced and found to be identical to the published sequence (except for the mutation site). Then, HEK-293 cells were co-transfected by calcium chloride with 10 μg of each of the vectors, 7.5 μg helper plasmid encoding gag-pol and 2.5 μg helper plasmid encoding vesicular stomatitis virus-G (VSV-G) proteins.
Web9 mrt. 2024 · Hepatocytes were isolated from STAT3 LKO mice for experiments 7 days post-injection when hepatocyte STAT3 loss was confirmed by Western blotting. Glucose, insulin and pyruvate tolerance tests were performed as described 43, 47 in mice fasted 5–6 hrs (glucose and insulin tolerance) or overnight (~16 hrs, pyruvate tolerance). Web20 jun. 2016 · STAT3 is therefore a novel player of the PKM2/HIF-1α feedback loop, since HIF-induced PKM2 activates STAT3 that in turn induces HIF-1α expression. These findings have profound implications …
Web9 mrt. 2024 · As expected, STAT3 expression was virtually absent in hepatocytes of mice administered the Cre virus (Fig. 5F ). In STAT3 flox-GFP control hepatocytes, LPA …
WebThese results demonstrate that the two classes of transcription factors, growth induced (STAT3 and AP-1) and tissue specific (HNF-1), can interact as an adaptive response to … old white terrierWebZhang, J., Li, N., Xu, Q.-Y., Yang, Y., Xie, H.-B., Shen, T., & Zhu, Q. (2024). Kupffer cell depletion attenuates IL-6/STAT3 mediates hepatocyte apoptosis in ... old white tennis shoesWeb30 jul. 2007 · Hepatocyte DNA synthesis in the survived L- Stat3−/− mice slightly decreased as compared with Stat3f/+ mice at 40 h after partial hepatectomy, whereas … isagi world cupWeb20 mrt. 2024 · STAT3 is an important transcription factor in the pathogenesis of LF. Tang et al. loaded STAT3-targeting antisense oligonucleotide and small interference RNA (siRNA) onto MSC-EXOs separately, and with the delivery advantage of exosomes, these two approaches effectively suppressed STAT3 levels and ameliorated LF in LF mice ( 102 ). old white tpc greenbrierWeb24 feb. 2024 · A significant decrease in hepatocyte glycogen and an increase in hepatocyte lipids were detected in the histological assay that coincidence with the hepatic gene expression. ... The role of IL-6 and STAT3 in inflammation and cancer. Eur. J. Cancer 2005, 41, 2502–2512. [Google Scholar] isagi yoichi heightWebSTAT3 induces and maintains a pro-carcinogenic inflammatory microenvironment, completing the link between inflammation and cancer. 7 Aberrant activities of STAT3 actively contribute to CRC, especially persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth. 8 miR-124 could target … is a glaive a monk weapon dndWeb14 apr. 2024 · TYK2 inhibitory drugs decrease activation of STAT3 while increasing activation of ERK1/2 in MPNST cells. A, JW23.3 cells and (B) JH-2–002 cells were incubated with a TYK2 inhibitor (40 μmol/L WU-12) or vehicle control for the indicated times. Phosphorylated and total protein levels for STAT3 and ERK1/2 were analyzed by the … old white trucks for sale