Dynamics of an oncolytic virus model
WebFeb 15, 2024 · Semantic Scholar extracted view of "Global dynamics of reaction-diffusion oncolytic M1 virotherapy with immune response" by A. Elaiw et al. ... A new … WebFeb 1, 2024 · An ODE model for oncolytic virus dynamics with four parameters is discussed. Although it is hard to obtain the explicit expressions of coordinates of equilibria, we find distribution of equilibria qualitatively, and obtain the exact number of equilibria and their qualitative properties. We further give a complete analysis on local bifurcations ...
Dynamics of an oncolytic virus model
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WebMar 5, 2024 · Author summary Tumor therapy with replicating oncolytic viruses is based on the premise that if the tumor specific virus infects and is amplified by the tumor population and spreads sufficiently within the tumor, it will lead to eradication of the cancer. The outcome of this approach is an exercise in population dynamics, and, as in ecology, … WebMathematical modeling in biology has a long history as it allows the analysis and simulation of complex dynamic biological systems at little cost. A mathematical model trained on experimental or clinical data can be used to generate and evaluate hypotheses, to ask "what if" questions, and to perform …
WebAug 15, 2024 · Oncolytic viruses (OVs) offer a novel strategy for the treatment of HCC. The OVs have an inherent ability to cause direct tumor cell lysis while sparing normal tissue, as well as their capacity to stimulate potent immune responses directed against uninfected tumor cells and distant metastases, resulting in an elegant multimodal therapy … Webwork. A predictive model of a complex in vivo situation (e.g. including immune responses) will obviously be more difficult to attain, but can arise from a thorough understanding of the simpler in vitro scenario that we examine here. Results The modeling framework We will model the dynamics of oncolytic virus replication by
WebMar 22, 2016 · Basic model of virus dynamics, and its application to oncolytic virus dynamics. A basic framework to study virus dynamcis in the context of a variety of human pathogens 11 takes into account three populations: uninfected cells, x, infected cells, y, and free virus, v. The model is given by ordinary differential equations, that describe the ... WebMar 3, 2024 · A schematic diagram of the model, depicting the interactions between the susceptible and infected tumor cells, innate and adaptive immune cells, and the virus. Susceptible tumor cells become infected by the oncolytic virus, and following successful viral replication within the infected cells, these cells lyse to give rise to new viral particles.
WebDec 6, 2024 · Author summary Oncolytic virotherapy is a promising form of cancer treatment that uses viruses to target, infect and kill cancer cells. Unfortunately, this form of therapy is often not effective, due to the occurrence of virus-resistant tumor cells. As it is challenging to assess the emergence and spread of resistance experimentally or in …
Webdescribing the dynamics in local neighborhoods in the agent-based model can predict the outcome of the spatial virus-cell dynamics, which has important practical implications. This analysis provides a first step towards understanding spatial oncolytic virus dynamics, upon which more detailed investigations and further complexity can be built. millis facebookWebEquid alphaherpesvirus 1 (EHV-1) causes respiratory diseases, abortion, and neurological disorders in horses. Recently, the oncolytic potential of this virus and its possible use in anticancer therapy has been reported, but its influence on cytoskeleton was not evaluated yet. In the following study, we have examined disruptions in actin cytoskeleton of … milli sec to hoursWebDec 21, 2024 · Oncolytic virotherapy is gaining interest in the clinic as a new weapon against cancer. In vivo administration of oncolytic viruses showed important limitations that decrease their effectiveness very significantly: the antiviral immune response causes the elimination of the therapeutic effect, and the poor natural ability of oncolytic viruses to … millisec to minutes convertermillis family dentalWebMay 16, 2024 · Mathematical models have provided significant biological insight into the field of virus dynamics, and similar approaches can be adopted to study oncolytic viruses. … millis family medicineWebMar 15, 2003 · Additional oncolytic virus species in development include vesicular stomatitis virus, polio virus, measles virus, Newcastle disease virus, ... The essential dynamics of the model are as follows. We assume that the uninfected tumor cells proliferate at rate λ. The virus infects tumor cells by binding to receptors on cell surfaces … millis extended dayWebApr 11, 2024 · Oncolytic virotherapy is an emerging novel tumor therapeutic approach that selectively replicates in and destroys tumor cells while leaving normal cells undamaged. … millis family health